Endocytosis gets in tune with action potential bursts
نویسندگان
چکیده
Neurons use a calcium-dependent mechanism to optimize the rate at which synaptic vesicles are recycled.
منابع مشابه
Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts
Modulation of synaptic vesicle retrieval is considered to be potentially important in steady-state synaptic performance. Here we show that at physiological temperature endocytosis kinetics at hippocampal and cortical nerve terminals show a bi-phasic dependence on electrical activity. Endocytosis accelerates for the first 15-25 APs during bursts of action potential firing, after which it slows w...
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